MewGenius Answerbook Risk: High

Guillotina Boss Guide

Safest opener, biggest mistakes, and the cleanest way to beat Guillotina in Mewgenics.

HP 400 MV 3

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Before the fight

Prep notes

Quick setup notes before you commit to Guillotina.

Encounter setup

When it happens

Appears during a later home-base defense sequence after the Boneyard progression line.

Prep window

7 in-game days
4 retired cats

Team planning

Recommended

1 durable frontliner1 ranged damage dealer1 mobility / escape unit1 healer or stabilizer

Avoid

Slow units that cannot recover from pull or trample pressureCats that need tight formations to functionUnderbuilt retired cats with weak survivability

Fast answer

Read this first

Main idea

Claim open lanes early and do not start boxed near edges or objects. Use the first turns to deny easy approach paths instead of forcing damage.

Biggest mistakes

Standing in her approach lane: she tramples to close, then uses melee-range CC and damage.
Getting pulled into melee range: once grouped, follow-up AOE and throws punish you hard.

Winning line

Deny clean trample lanes with spread positioning and side-steps.
Keep at least one escape tile behind each unit to survive pull or knockback pressure.

Before you start

Quick-scan notes before you commit to the fight.

Quick scan

Safest opener

Claim open lanes early and do not start boxed near edges or objects.
Use the first turns to deny easy approach paths instead of forcing damage.
Hold a defensive response for bonus-turn sequences instead of greedily racing damage.
Respect trample lines and do not let your backline sit directly behind your frontline.

Bring / avoid

Bring: Mobility or spacing tools
Bring: Reliable ranged punishment
Bring: At least one sturdy unit that can survive a bad engage
Useful: Healing or stabilization
Useful: Reposition tools

Fight plan

The safest way to approach the fight without reading a wall of text.

Decision-first notes

Win conditions

Deny clean trample lanes with spread positioning and side-steps. Keep at least one escape tile behind each unit to survive pull or knockback pressure. Punish after Guillotina commits to a lane or a major melee action, not before.

Opener

Claim open lanes early and do not start boxed near edges or objects.
Use the first turns to deny easy approach paths instead of forcing damage.

Midfight

Bait a commit, then punish during her recovery positioning.
If a unit gets displaced, stabilize formation first before spending your best damage.

Finisher

Close only when lanes are safe.
Do not all-in while your team is clustered near her body or trapped near the map edge.

Detailed notes

Positioning, run killers, and loadout reminders.

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Run killers

Standing in her approach lane: she tramples to close, then uses melee-range CC and damage.
Getting pulled into melee range: once grouped, follow-up AOE and throws punish you hard.
Letting the 2x2 body pin you near edges or corners: you lose escape tiles and die to follow-up.

Positioning rules

Never stack in a straight line in front of her.
End turns with 1–2 open tiles behind your units whenever possible.
Fight in open space; avoid corners where a 2x2 body can trap your team.
Do not over-clump your backline behind a single frontline unit.

Loadout hints

Mobility or spacing tools Reliable ranged punishment At least one sturdy unit that can survive a bad engage

Healing or stabilization Reposition tools Backline damage that works without clumping

Over-clumped melee-only setups Slow teams with poor recovery after displacement Fragile carries with no safe reposition plan

Source: house-fights.csv + site editorial synthesis · Last tested: 2026-03-30 · Some move values are still being confirmed in live runs.

Detailed notes

Mechanics, background notes, extra item links, and deeper context.

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About Guillotina

Guillotina is a large 2x2 bruiser-style boss that becomes dangerous once she closes into melee. Most losses come from bad spacing, getting trapped near edges, or allowing her clean trample and pull lanes.

Type: Boss Role: 2x2 Bruiser / Home Defense Pressure Bruise Knockback

Mechanics snapshot

Main mechanics

Bonus Turns Trample Throw AOE Zone Pull

Key triggers

Actively seeks to walk over units to close distance. Becomes most dangerous once she reaches melee range. Pull and displacement effects become much harder to recover from near edges and corners.

Moves to know

Toss

Throws an adjacent unit across the map; collision damage is still being verified.

Vacuum Mouth

Pulls units in a straight line toward her mouth.

Jump Slam

Jumps and slams within close range; likely followed by bruising or knockback pressure.

Unverified phase notes

Extra observations that still need more confirmation.

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Some community notes mention a possible body/head split, but this is not stable enough to plan around yet.
Until fully verified, treat Guillotina primarily as a 2x2 trample bruiser with pull and melee follow-up.
Do not route your whole strategy around split-phase assumptions.

FAQ

Quick answers to the most common questions about this fight.

How do you beat Guillotina in Mewgenics? ▾

Deny clean trample lanes, keep escape tiles behind your units, and only punish after Guillotina commits to a lane or major melee action.

How do you prepare for Guillotina? ▾

Bring four retired cats with balanced roles: one frontliner, one ranged damage dealer, one mobility unit, and one healer or stabilizer. The safest prep is role balance, not a greedy damage-only setup.

Where does Guillotina appear? ▾

Guillotina appears during a later home-base defense sequence after the Boneyard progression line.

What counters Guillotina? ▾

Spacing, mobility, safe lane control, and ranged punishment after she commits are the most reliable counters.